Ultrastructural Characterization of Novel Intracisternal Virus-Like Particles Associated with a Spontaneous Subcutaneous Tumor from a Japanese Wild Mouse, Mus musculus molossinus (Mon/Nm).

Autor: HOSHINO, Munemitsu, IMAI, Masao, NAGAYOSHI, Shoichi, SAGA, Shinsuke, TAKAHASHI, Masahide, GIL, Jollyanna MALAVASI, HAYAKAWA, Seijun, YOKOI, Toyoharu, AOYAMA, Atsuko, TAKENAKA, Tokuya, KONDO, Kyoji
Zdroj: Journal of Electron Microscopy; Oct1985, Vol. 34 Issue 4, p389-397, 9p
Abstrakt: Ultrastructure of a new type of intracisternal virus-like particles (Mol-P) found in a subcutaneous tumor from a Japanese wild mouse, , was described. MoI-Ps were observed in two forms: as budding particles at the membrane of the rough endoplasmic reticulum (r-er) and as free particles, 120 nm In average diameter, In the cisternae. The envelopes of budding forms were continuous with the r-er membrane and each contained a small dense core, 45 nm in average diameter. The free forms were round, oval, or pear- shaped, and were bounded by an envelope with a unit membrane structure. Different from the coexisting intracisternal A particles Identical in profile to those reported previously, the free forms were characterized by the presence of an eccentrically located nucleold. The nucleoid consisted of a small dense core surrounded by an intermediate membranous structure (IMS) about 5 nm thick. The IMS displayed either a closed-circular structure or a whirled, open-circular profile. In the latter IMS, one end was terminated at the envelope and the other at the core. Possible origins of Mol-P were discussed In relation to known retroviruses. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index