| Autor: |
Nau, Roland, Prange, Hilmar W., Menck, Syivia, Kolenda, Herbert, Visser, Klaus, Seydel, Joachim K., Nau, R, Prange, H W, Menck, S, Kolenda, H, Visser, K, Seydel, J K |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Jun1992, Vol. 29 Issue 6, p719-724, 6p |
| Abstrakt: |
The penetration of rifampicin into CSF was studied in seven patients who had undergone external ventriculostomy for occlusive hydrocephalus without major disturbance of the blood-CSF barrier. After the first dose of rifampidn 600 mg iv over 3 h, blood and CSF concentrations were determined serially by HPLC. Peak CSF concentrations obtained 0–8 h (median = 1 h) after the end of the infusion ranged from 0·57 to 1·24 mg/L (median = 0·73 mg/L). Elimination from CSF was slower than from serum (: 9·1–21·0 h (median = 14·5 h, = 5); 1/2βxf: 2·2–3·8 h (median = 3·6 h, = 7)). Based on the ratios of the areas under the concentration-time curves in CSF and serum, the overall penetration of rifampicin into CSF was 0·13–0·42 (median = 0·22). These results demonstrate effective CSF penetration and favourable pharmacokinetics of rifampicin in the absence of meningeal inflammation. They support the use of rifampicin as part of a combination therapy not only for tuberculosis of the central nervous system (CNS), but also for staphylococcal and listerial infections of the CNS in which there may be little meningeal inflammation. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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