A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: antimicrobial prophylaxis must include gram-positive cover.

Autor: Morris, D. L., Wilson, S. Rodgers, Pain, J., Edwardson, K. F., Jones, J., Strachan, C., Slack, R., Wilson, S R
Zdroj: Journal of Antimicrobial Chemotherapy (JAC); Apr1990, Vol. 25 Issue 4, p673-678, 6p
Abstrakt: Aztreonam/metronidazole and cefotaxime/metronidazole were compared in a prospective trial in 154 patients undergoing elective colorectal surgery. Three antibiotic doses were given over 16 hours. A significant excess of wound sepsis in the aztreonam group was seen (23/71 vs 9/70 chi 2 6.60; P less than 0.01). Sepsis was almost invariably due to Gram-positive organisms and, in particular, Staphylococcus aureus. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index