| Autor: |
Greenwood, David, Bidgood, Karen, Turner, Mark, Greenwood, D, Bidgood, K, Turner, M |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Aug1987, Vol. 20 Issue 2, p155-164, 10p |
| Abstrakt: |
Continuous turbidimetric monitoring of cultures of staphylococci and streptococci exposed to teicoplanin or vancomycin revealed considerable inhibitory activity at concentrations below the conventionally-determined minimum inhibitory concentration. Teicoplanin was more active than vancomycin against low inocula, but exhibited a larger inoculum effect. A modest decline in susceptibility to teicoplanin and vancomycin could be induced by sequential exposure to the drugs. Such variants gradually reverted to susceptibility on passage in antibiotic-free broth. The morphological consequences of exposure to the two antibiotics were similar as judged by scanning electron microscopy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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