| Autor: |
McColm, A. A., Shelley, E., Ryan, D. M., Acred, P. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Dec1986, Vol. 18 Issue 5, p599-608, 10p |
| Abstrakt: |
The activity of ceftazidime was examined in a murine model of pneumonia in which the antibiotic was administered subcutaneously 6 h after intra-nasal infection and then twice daily for the next three days (i.e. seven doses). In a series of experiments using this test, the dose of ceftazidime giving 50% survival relative to controls (SD) ranged from 1.0–9.0 mg/kg/dose while the dose required to reduce the log cfu/lung by 50% (CD) ranged from 24–64 mg/kg/dose. Ceftazidime was considerably more effective than cefotiam, amoxycillin-clavulanic acid or kanamycin in the test. Pharmacokinetic studies with ceftazidime showed that no differences in respiratory tract penetration existed between uninfected mice and mice infected for 48 h with . The percentage penetration of ceftazidime from serum was 73% for pleural fluid, 44% for tracheal fluid, 27% for tracheal wall tissue and 17% for whole lung tissue after a subcutaneous injection of 100 mg/kg. At this dose, ceftazidime remained at supra-MIC concentrations for 2–3 h in all compartments examined. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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