| Autor: |
Neu, Harold C., Chin, Nai-Xun, Labthavikul, Pornpen |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Aug1986, Vol. 18 Issue 1, p35-44, 10p |
| Abstrakt: |
Carumonam is a monobactam with a beta-carbamyloxymethyl group at position 4. It inhibited 90% of Enterobacteriaceae at ≤8 mg/l and had in-vitro activity similar to that of cefotaxime, ceftazidime and aztreonam. Fifty per cent of and isolates were inhibited by 4 mg/l, but isolates resistant to aztreonam and ceftazidime were not inhibited. Carumonam, like aztreonam, did not inhibit Gram-positive or anaerobic species. Carumonam was not destroyed by the common plasmid- and chromosomally-mediated β-lactamases and was more stable than aztreonam to attack by the K-l β-lactamase of . Carumonam inhibited Richmond-Sykes type Ia and Id β-lactamases but was a poor inhibitor of type III enzymes. It did not induce β-lactamases. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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