Comparison of the effect of phenoxymethylpenicillin, cloxacillin, and flucloxacillin on Staphylococcus aureus phagocytosed by human monocytes.

Autor: van den Broek, P. J., Buys, L. F. M., Mattie, H., van Furth, R.
Zdroj: Journal of Antimicrobial Chemotherapy (JAC); Jul1986, Vol. 17 Issue 6, p767-774, 8p
Abstrakt: The antibacterial effect of phenoxymethylpenicillin, cloxacillin, and flucloxacillin on pre-opsonized ingested by human monocytes and on pre-opsonized in suspension was compared. The antibiotics were 1.7–3 times more effective against intracellular than against in suspension. No influence of acid stability or lipid solubility of the drugs on the antibacterial effect against intracellular was demonstrated. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index