| Autor: |
Greenman, R. L., Arcey, S. M., Dickinson, G. M.., Mokhbat, J. E., Sabath, L. D., Platt, T. B., Friedhoff, L. T. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); May1985, Vol. 15 Issue 5, p637-640, 4p |
| Abstrakt: |
Cerebrospinal fluid of aztreonam were measured in 11 patients with meningeal inflammation. Two to eight hours after a single 2 gin intravenous dose, CSF aztreonam levels ranged from 0·76 to 16·6 mg/l. The mean CSF concentration in four patients with viral meningitis was 1·28 mg/l, which was lower than the mean con centration of 7·2 mg/l in the five with bacterial, cryptococcal or carcinomatous meningitis. Two patients with infected subdural drains were also sampled serially and had CSF levels greater than 1 mg/l between 1 and 8 h post dose. Penetration of aztreonam into the CSF in the presence of meningeal inflammation appears adequate to warrant therapeutic trials in patients infected with susceptible organisms. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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