| Autor: |
Saito, Masato, Saito, Takeshi, Yano, Kuniichiro, Shibata, Kazuo, Nishino, Takeshi, Tanino, Teruo, Saito, M, Saito, T, Yano, K, Shibata, K, Nishino, T, Tanino, T |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Feb1984, Vol. 13 Issue 2, p133-142, 10p |
| Abstrakt: |
The therapeutic activities of cefotetan against experimentally induced infections with Escherichia coli. Serratia marcescens, Bacteroides fragilis or Fusobacterium mortiferum in the granuloma pouches of rats were compared with those of cefmetazole and cefazolin. Of these antibiotics, cefotetan showed the greatest therapeutic effect against the four bacterial infections after a single intramuscular administration. Cefotetan was found to give much higher pouch exudate concentrations than cefmetazole, and to show prolonged antibacterial levels even when compared with cefazolin. In the granuloma pouch, cefotetan produced similar morphological changes in the cells of E. coli NY-17 as have been observed in vitro by microscopy. Elongation and bulge formation were noted. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
