| Autor: |
Boscia, Jerome A., Korzeniowski, Oksana M., Kobasa, William D., Rocha, Heonir, Levison, Matthew E., Kaye, Donald, Boscia, J A, Korzeniowski, O M, Kobasa, W D, Rocha, H, Levison, M E, Kaye, D |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Oct1983, Vol. 12 Issue 4, p407-410, 4p |
| Abstrakt: |
The pharmacokinetics of cefoperazone were studied and compared in four normal subjects and six patients with hepatosplenic schistosomiasis (HSS) with mild liver disease but marked portal hypertension. All subjects received a 2 g intravenous infusion of cefoperazone over 15 min. Although most pharmacokinetic parameters did not differ significantly between normal subjects and patients with HSS, the serum β half-life of cefoperazone was longer in patients with HSS compared to normal subjects (3.0 h vs. 1.7 h). This demonstrates only mild impairment of excretion of cefoperazone in patients with HSS. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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