| Autor: |
Davies, B. I., Maesen, F. P. V., Jevons, S., Brouwers, J., Maesen, F P |
| Předmět: |
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| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Nov1982, Vol. 10 Issue 5, p445-452, 8p |
| Abstrakt: |
A group of 20 patients with acute exacerbations of chronic bronchitis was treated with the combination of 750 mg sulbactam pivoxyl (CP-47,904) with 800 mg bacampicillin orally twice daily for 10 days. The infections were caused mainly by Haemophilus influenzae, Streptococcus pneumoniae and Branhamella catarrhalis, and five patients had -lactamase-forming infecting strains. Cultures were repeated on study days 10 and 17. Peak blood concentrations of ampicillin (mean 12 1 mg/l) were found 1·6 h after the first dose: the mean sputum peak concentration was 0·22 mg/l. The peak concentration of -lactamase inhibitor in the blood was found 1·8 h after dosage and averaged 7·2 mg/l. Sputum concentrations of sulbactam were less than the lower limit of sensitivity of the assay method (0·5 mg/l) in all but one patient. The penetration of ampicillin from blood to sputum was approximately 3%. The clinical results were encouraging, as 15 of the 19 evaluable patients yielded excellent or good results on day 17. One patient developed severe nausea and another had severe diarrhoea and one patient dropped out because of a hypersensitivity rash. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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