| Autor: |
Cook, R. M., Browne, M. J., Boyd, M. R. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Jul1982, Vol. 10 Issue 1, p43-48, 6p |
| Abstrakt: |
Intranasal infection of Balb/c mice with influenza A/Hong Kong/1/68 (H3N2) virus resulted in the appearance of viable virus in the lungs, which reached peak titre within 72 h of infection. Virus titres were maintained until day six after infection and all virus was eliminated by day eight. Intranasal treatment of mice with the double stranded polyribonucleotide interferon inducer BRL 5907 24 h before infection significantly reduced lung virus titres, although it failed to prevent infection. Similar reductions in titre were obtained following the administration of rimantadine and ribavirin. Treatment of infected mice with the immunomodulators levamisole and isoprinosine was without effect. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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