| Autor: |
Lawrence, Ruth M., Hoeprich, Paul D., Jagdis, Franklyn A., Monji, Nobuo, Huston, Alice C., Schaffner, Carl P., Lawrence, R M, Hoeprich, P D, Jagdis, F A, Monji, N, Huston, A C, Schaffner, C P |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Mar1980, Vol. 6 Issue 2, p241-249, 9p |
| Abstrakt: |
Either doubly radiolabelled amphotericin B methyl ester hydrochloride (AME) or amphotericin B deoxycholate (AMB) was infused as a single intravenous dose into rhesus monkeys (). Twenty-four hours later, the animals were killed by exsanguination, and tissues and liquids were obtained for measurements of radioactivity and bioactive drugs. AME was not de-esterified. The AMB deoxycholate complex dissociated and the components were handled differently in the body. The highest concentrations of both drugs were found in the bile. AME in a dose of 5 mg/kg body weight accumulated in the lung in amounts 12 to 46 (mean: 23) times greater than AMB in a dose of 1 mg/kg body weight. In the kidneys, AME exceeded AMB 3 to 10 (mean: 6) times, and attained concentrations 12 to 22 times greater than AMB in the urine. Neither drug accumulated in brain or cerebrospinal fluid. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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