| Autor: |
Tally, Francis P., Jacobus, Nilda V., Barza, Michael, Tally, F P, Jacobus, N V, Barza, M |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Mar1979, Vol. 5 Issue 2, p159-165, 7p |
| Abstrakt: |
The susceptibility of anaerobic and aerobic bacteria to cefaclor, cephalexin, and penicillin G were compared. Cefaclor was two- to fourfold more inhibitory than cephalexin against susceptible Gram-negative bacilli and . Both drugs were active against streptococci and anaerobes other than but were distinctly less potent than penicillin G. Ultrafiltration serum protein-binding studies revealed that cefaclor was approximately 50% bound while the corresponding value for cephalexin was only 17 to 20%. The results indicate that cefaclor is moderately more active than cephalexin against and susceptible Gram-negative bacilli, but suggest that oral cephalosporins should be used with caution in anaerobic infections. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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