| Autor: |
Brodwall, E. K., Bergan, T., ørjavik, O., Orjavik, O |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Nov1977, Vol. 3 Issue 6, p585-592, 8p |
| Abstrakt: |
Intramuscular doses of 0.5 g cefazolin were given to 17 patients with varying degrees of reduced renal function. Urinary concentrations of cefazolin were only appreciably reduced below glomerular filtration rates of 30 ml/min. During the first 12 h, 85 ±11% of the dose appeared in the urine in active form. The protein binding was 86±2% and was not reduced with renal function down to 10 ml/min. Cefazolin is excreted both by glomerular filtration and secretion through the tubular epithelial cells. Tubular secretion amounts to 50 to 80% of the active compound excreted down to an inulin clearance of 25 ml/min. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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