| Autor: |
Brogan, T. D., Neale, Lynne, Ryley, H. C., Davies, B. H., Charles, J., Neale, L |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); May1977, Vol. 3 Issue 3, p247-251, 5p |
| Abstrakt: |
The average concentration of minocycline in the sol phase of sputum from a series of patients on a dose of 200 mg/day was 0.83±1.0 μg/ml; this level, which was 60% of the serum level of the drug, was not significantly different from the average antibiotic concentration in sputum specimens from a group of patients receiving 2 g/day oxytetracycline. Sputum minocycline levels were significantly related to the serum concentrations achieved by the oral dose but unrelated to the concentrations of albumin and transferrin in the sputum sol phase. It was suggested that the intrabronchial concentration of minocycline during therapy is not dependent on the inflammatory response of the pulmonary vascular bed and that minocycline is actively secreted into the bronchial lumen by the cells and glands of the bronchial epithelium. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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