| Autor: |
Sadatsuki, M., Tsutsumi, O., Sakai, R., Eto, Y., Hayashi, N., Taketani, Y. |
| Zdroj: |
Human Reproduction; Sep1993, Vol. 8 Issue 9, p1392-1395, 4p |
| Abstrakt: |
We assessed the presence of an activin-like substance in human follicular fluid that was obtained from women undergoing in-vitro fertilization using a bioassay for activin A. Activin activity was not detected in crude follicular fluids; the bioactivity of standard activin A was inhibited by the addition of follicular fluid. After the follistatin (binding protein of activin A) was removed from follicular fluid using a purification procedure, activin activity was detected in the follicular fluids (mean concentration: 131 ± 40 ng/ml). Activin activity was inhibited by the addition of follistatin to fluid. The concentration of activin activity was substantially higher (∼100-fold) than that reported in serum. The concentration negatively and significantly correlated with the number of developed follicles in the ovary ( = 0.501, < 0.01). These results suggest that activin A and its binding protein are present in follicular fluid in large amounts and that they may have a role in local ovarian regulation. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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