| Autor: |
Wang, Zuoyuan, Boice, John D., Wei, Luxin, Beebe, Gilbert W., Zha, Yongru, Kaplan, Michael M., Too, Zufan, Maxon, Harry R., Zhang, Shouzhi, Schneider, Arthur B., Tan, Bingde, Wesseler, Terrence A., Chen, Deqing, Ershow, Abby G., Kleinerman, Ruth A., Littlefield, L. Gayle, Preston, Dale |
| Zdroj: |
JNCI: Journal of the National Cancer Institute; 3/17/1990, Vol. 82 Issue 6, p478-485, 8p |
| Abstrakt: |
Thyroid nodularity following continuous low-dose radiation exposure in China was determined in 1,001 women aged 50–65 years who resided in areas of high background radiation (330 mR/yr) their entire lives, and in 1, 005 comparison subjects exposed to normal levels of radiation (114 mR/yr). Cumulative doses to the thyroid were estimated to be of the order of 14 cGy and 5 cGy, respectively. Personal interviews and physical examinations were conducted, and measurements were made of serum thyroid hormone levels, urinary iodine concentrations, and chromosome aberrations in circulating lymphocytes. For all nodular disease, the prevalences in the high background and control areas were 9.5% and 9.3%, respectively. For single nodules, the prevalences were 7.4% in the high background area and 6.6% in the control area (prevalence ratio = 1.13; 95% confidence interval = 0.82–1.55). There were no differences found in serum levels of thyroid hormones. Women in the high background region, however, had significantly lower concentrations of urinary iodine and significantly higher frequencies of stable and unstable chromosome aberrations. Increased intake of allium vegetables such as garlic and onions was associated with a decreased risk of nodular disease, which seems consistent with experimental studies suggesting that allium compounds can inhibit tumor growth and proliferation. The prevalence of mild diffuse goiter was higher in the high background radiation region, perhaps related to a low dietary intake of iodine. These data suggest that continuous exposure to low-level radiation throughout life is unlikely to appreciably increase the risk of thyroid cancer. However, such exposure may cause chromosomal damage. [J Natl Cancer Inst 82: 478–485, 1990] [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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