| Autor: |
Nourigat, Cynthia, Badger, Christopher C., Bernstein, Irwin D. |
| Zdroj: |
JNCI: Journal of the National Cancer Institute; 1/6/1990, Vol. 82 Issue 1, p47-50, 4p |
| Abstrakt: |
We have previously shown that I-labeled monoclonal antibodies against the Thy1.1 differentiation antigen can induce the regression of Thy1.1 antigen-positive (Thy1.1) AKR/J SL2T cell lymphoma nodules in AKR/Cum (Thy1.2) mice. In this study, we examined the ability of I-labled anti-thy1.1 antibodies to eliminate tumor nodules containing vairant lymphoma cells that do not express the Thy1.1 antigen (Thy1.1). AKR/Cum mice were sc inoculated with mixtures of 1–2 × 10 AKR/J SL2 cells and varying amounts (0.3%–10%) of Lsp3, a Thy1.1 antigen-negative (Thy1.1) subclone of the SL2. One week later, when an established tumor nodule was present, mice were treated with 1,500–1,700 μCi of I-labled anti-thy1.1 antibody. Complete regression of tumor was observed in 11 of 12(92%) mice inoculated with tumor containing 0.3%–1% antigen-negative cells. In contrast, nocomplete regressions were observed in mice with only antigen-negative tumor cells treated with I-labled anti-thy1.1 antibody or in mice inoculated with antigen-positive tumor and treated with an I-labled control antibody. Of the mice receiving mixtures containing 3%–10% antigen-negative cells, five of seven showed complete regression. These results demonstrate that radiolabled antibodies can eliminate small numbers of antigen-negative tumor cells present within a tumor mass. [J Natl Cancer Inst 82:47–50, 1990] [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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