| Autor: |
Rosenberg, Steven A., Schwarz, Susan L., Spiess, Paul J. |
| Zdroj: |
JNCI: Journal of the National Cancer Institute; 9/1/1988, Vol. 80 Issue 17, p1393-1397, 5p |
| Abstrakt: |
Attempts have been made to design optimal strategies for the immunotherapy of established tumors. In micebearing pulmonary metastases from sarcomas, a substantial therapeutic synergy was seen when bothinterleukin-2(IL-2) and alfa interferon(α-IFN) were administered compared with the effect of either agentgiven alone. This synergy was dependent on Lyt-2T cells, since therapeutic effects were abrogated in Lyt-2 depleted mice. The αIFN and IL-2 combination was also synergistic with tumor-infiltrating lymphocytes inmediating the reduction of established lung metastases. These experiments demonstrate that combination immunotherapy can result in substantial reduction of established metastatic deposits and provide a rationale for the application of this treatment to patients with advanced cancer. [J National Cancer Inst 1988;80:1393–1397] [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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