| Autor: |
Beland, Frederick A., Dooley, Kenneth L., Sheldon, Winslow G., Delongchamp, Robert R. |
| Zdroj: |
JNCI: Journal of the National Cancer Institute; 3/3/1988, Vol. 80 Issue 5, p325-330, 6p |
| Abstrakt: |
Male C57BL/6N mice were administered a single ip injection of 30 mg of - methyl--nitrosourea (MNU)/kg of body weight. Additional groups were treated similarly every 3 hours for the next 24 hours. Adenocarcinomas of the small intestine were the major treatment-related tumors, with the total incidence being 38% at 250 days after injection. There was a significant circadian variation for tumor induction; the maximum number of intestinal tumors (≈55%) tended to occur when the MNU was administered during the middle of the light period (6:00 to 18:00), while the tumor incidence was at a minimum (≈10%) when the MNU was given in the middle of the dark phase (18:00 to 6:00). These data are discussed in relation to DNA synthesis and repair and MNU-induced cellular toxicity. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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