| Autor: |
GREEN, MANFRED S, SHOHAT, TAMY, LERMAN, YEHUDA, COHEN, DANI, SLEPON, RAPHAEL, DUVDEVANI, PORIYA, VARSANO, NOEMI, DAGAN, RON, MENDELSON, ELLA, Green, M S, Shohat, T, Lerman, Y, Cohen, D, Slepon, R, Duvdevani, P, Varsano, N, Dagan, R, Mendelson, E |
| Zdroj: |
International Journal of Epidemiology; Oct1994, Vol. 23 Issue 5, p1078-1081, 4p |
| Abstrakt: |
Background: Following vaccination of children using high-titre live measles vaccine, excess non-specific mortality was reported, particularly among females. Since vaccination with live measles virus results in a temporary depression of the immune response to other antigens, the female predominance in subsequent non-measles mortality may be due to sex differences in response to live measles vaccines.Methods: In this study, the immunogenicity of standard titre live Schwarz strain measles vaccine was examined 2 and 4 weeks post-vaccination in 223 males and 66 female aged 18-20 years in Israel in 1991.Results: Females had higher post-vaccination geometric mean titre (GMT) at all levels of pre-vaccination titres at both 2 and 4 weeks. Furthermore, after controlling for differences in pre-vaccination titres, overall the post-vaccination GMT for females was about 50% higher than for males (P < 0.001).Conclusions: These findings indicate that females exhibit a stronger humoral immune response to measles vaccine. Possible sex differences in immunosuppression following measles vaccination should be explored. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
