| Autor: |
Ferrick, David A., Cho, Kiho, Gemmell-Hori, Lorraine, Morris, David W. |
| Zdroj: |
International Immunology; Jul1992, Vol. 4 Issue 7, p805-810, 6p |
| Abstrakt: |
In this report, the T cell repertoire was studied In a natural genetic model system using a novel mouse strain (WXG-2) carrying a single pathogenic mouse mammary tumor virus (MMTV) provirus () on an otherwise MMTV-free genetic background. The provirus has complete biological activity, produces infectious mllk-transmltted virus, and contributes to mammary carclnogenesis by an insertion mutation mechanism. In mice carrying the provirus, T cells expressing V14 were specifically deleted in mice with a functional MHC class II I-E gene but not in I-E controls. The deletion of V14 T cells was more rapid in mice with the provirus than in -free control mice infected with exogenous MMTV. In addition, the deletion phenotype was age dependent. A slow depletion of V14 T cells was observed, and >95% of the V14 T cells were eliminated by 6 months of age. These experiments Indicate that (i) the provirus encodes or regulates expression of a V14-specific superantigen, (ii) interactions between and other MMTV proviruses are not necessary for the V14 deletion phenotype, (ill) the presence of a retroviral superantigen in all cells is not sufficient for T cell depletion during neonatal development in the thymus, and (iv) the provirus and Its associated exogenous provirus have the same V specificity. The biological implications of this viral function are presently unknown; however, it is clear that MMTV can have profound effects on the immune system and these effects may ultimately prove to be involved in viral pathogenesis. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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