| Autor: |
Voss, Lesley M., David, Chella S., Showalter, Stephen D., Paya, Carlos V., Leibson, Paul J. |
| Zdroj: |
International Immunology; Mar1992, Vol. 4 Issue 3, p417-420, 4p |
| Abstrakt: |
Heteroconjugate antibodies are generated by covalently linking two mAbs with different specificities. When antl-CD3 mAb, capable of activating effector T cells, is coupled to anti-herpes simplex virus (HSV) mAb, which binds HSV antigens on virally-lnfected target cells, the resulting heteroconjugate antibody can be used to enhance anti-HSV immunity. Specifically, these heteroconjugate antibodies can augment antl-HSV immunity among lymphocytes previously lacking cytotoxicity against HSV-infected target cells. However, the efficacy of these specialized reagents in enhancing anti-HSV Immunity has not been determined. We report here that anti-HSV heteroconjugates used In an adoptive transfer murine model of HSV-1 infection inhibited HSV replication and Improved long-term survival. These results demonstrate that heteroconjugate antibodies have a potential therapeutic role in enhancement of anti-HSV immunity. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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