The peptide pyroGlu-Gln-Gly-Ser-Asn, isolated from mouse liver, inhibits growth of rat hepatoma cells in vitro.

Autor: Paulsen, Jan Erik, Sundby-Hall, Kirsten, Endresen, Liv, Rugstad, Hans Erik, Reichelt, Karl Ludvig, Elgjo, Kjell
Zdroj: Carcinogenesis; 1991, Vol. 12 Issue 2, p207-210, 4p
Abstrakt: The peptide pyroGlu-Gln-Gly-Ser-Asn, recently isolated from mouse liver, inhibited DNA synthesis and proliferation of MHC cells, a rat clonal strain derived from a Morris transplantable hepatoma. Both the biological peptide isolated from mouse liver and the synthetic homolog showed bell-shaped dose-response curves. Maximal inhibition (˜50%) was observed at two separate dose ranges: one at 10–10 M, and one at 10–10 M. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index