| Autor: |
Farrelly, James G., Saavedra, Joseph E., Kupper, Robert J., Stewart, Mary L. |
| Zdroj: |
Carcinogenesis; 1987, Vol. 8 Issue 8, p1095-1099, 5p |
| Abstrakt: |
The metabolism of -nitrosobis(2-oxopropyi)amine (BOP) was examined in microsomes from uninduced F-344 rats. Even when the conditions were varied, no metabolism of this compound was detected. On the other hand, freshly isolated hepatocytes from F-344 rats metabolized BOP efficiently to CO. The kinetics of conversion showed there were at least two components. The high affinity component had a of 0.13 mM while the lower had a of 1.3 mM. As products of the metabolism, -nitroso{2-hydroxypropyl)(2-oxopropyl)-amine (HPOP) and -iutrosobis(2-hydroxypropyl)amine (BHP) were found whereas little acetol and no -nitroso-methyl-2-oxopropylamine (MOP) were detected. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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