| Autor: |
Kohl, F.-V., Rüdiger, H.W. |
| Zdroj: |
Carcinogenesis; 1980, Vol. 1 Issue 9, p733-737, 5p |
| Abstrakt: |
Retinoids are known to inhibit the substrate mediated enzyme induction of benzo[a]pyrene metabolizing enzymes. Consequently, the effect of two retinoids on the induction of benzo[a]pyrene metabolizing enzymes by the more potent inductor 2,3,7,8-tetrachlorodibenzo--dioxine (TCDD) was investigated. The studies were performed with human diploid fibroblasts in culture. Vitamin A palmitate and all--retinoic-acid were found to prevent the TCDD induced increase of benzo[a]-pyrene metabolism in a dose-dependent manner. The fact that this effect was immediately reversible makes it unlikely that it was due to non-specific toxic effects. The data suggest that retinoids cause a preferential inhibition of the synthesis of benzo[a]pyrene metabolizing enzymes. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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