| Autor: |
LÜBBECKE, F., ZSCHäTZSCH, S., MITROVIC, V., HUSSEINI, H., SCHLEPPER, M., LASCH, H. -G., SCHüTTERLE, G., WlZEMANN, V. |
| Zdroj: |
European Heart Journal; Jan1991, Vol. 12 Issue 1, p88-91, 4p |
| Abstrakt: |
In 28 patients with first myocardial infarction plasma catecholamines and thrombocyte alpha-adrenoceptors were studied. The first determination (by HPLC and radioligand binding, respectively) was performed immediately after hospital admission and 6 weeks later. In the acute phase of myocardial infarction plasma adrenaline and noradrenaline levels were high. No significant differences in thrombocyte alpha-adrenoceptors and plasma concentrations of adrenaline and noradrenaline were observed between diabetic and non-diabetic patients. In three non-surviving patients only the affinity of the alpha-adrenoceptor to the radioligand was decreased (P < 0.05), the relatively high catecholamine levels failed to reach statistical significance. Six weeks after hospital admission, adrenaline plasma levels were significantly decreased in diabetic and non-diabetic patients, while noradrenaline was only lowered in non-diabetic patients (P < 0.05). Only in this group did the receptor number (B) show a significant elevation 6 weeks after hospital admission. We conclude that, in acute myocardial infarction, alpha-adrenoceptors mainly interact with noradrenaline. Accordingly, no adrenoceptor alteration occurred in diabetic patients, who showed only a decrease in adrenaline but not in noradrenaline plasma concentrations 6 weeks following myocardial infarction. The different patterns in diabetic and non-diabetic patients suggest an alteration of catecholamine metabolism in diabetes mellitus. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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