| Autor: |
VAN EENIGE, M. J., VISSER, F. C., DUWEL, C. M. B., ROOS, J. P. |
| Zdroj: |
European Heart Journal; Mar1990, Vol. 11 Issue 3, p258-268, 11p |
| Abstrakt: |
The results described in the literature of myocardial scintigraphy with radioiodinated heptadecanoic acid (IHDA) to detect coronary stenoses are contradictory. In the present study, IHDA scintigraphy was performed in nine control subjects and 67 patients with coronary artery disease. The acquisition time was 75 min and background correction was not applied. The time-activity curves of regions of interest were analysed by curve fitting with a monoexponential plus constant. Two parameters were used: the half time value of the monoexponential (T in min) and the ratio of the amplitude (A) of the monoexponential and the total activity at time t = 0 (amplitude + constant = A + C): A/A + C as a percentage. Based on the control group, a region of normal T values and A/A + C ratios was defined, for each calculated T-A/A + C pair the probability of originating from a normal region was calculated. The value of the IHDA test, using the index of merit (sensitivity + specificity-100% ), increased in the patient group without MI with the severity of the stenosis (21%,24% and 47% for stenoses≥ 75%, ≥90% and ≥99%). In patients with MI, only small positive values in regions ofnon-infarct-related vessels were found ( − 1 %−16% ). It is concluded that the value of the IHDA test to detect stenoses of coronary arteries is too low to apply this test in clinical practice. However, a new type of analysis is offered, based on curve fitting of individual pixels. Preliminary results indicate better results than analysis of regions of interest. In the pilot study a sensitivity of 72% and a specificity of 89% was found to detect significant coronary stenoses [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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