| Autor: |
O'KEEFE, J. C., MALTZ, M. B., BUTROUS, G. S., CAMM, A. J. |
| Zdroj: |
European Heart Journal; Oct1986, Vol. 7 Issue 10, p843-847, 5p |
| Abstrakt: |
Ten patients with chronic stable angina were treated with 4 incremental doses of tiapamil (200 mg, 400 mg, 600 mg and 800 mg) in a double-blind, placebo-controlled study. Treadmill exercise electrocardiograms were performed before and after single oral doses of tiapamil. A dose-dependent increase in exercise duration occurred after tiapamil with significant improvement after tiapamil 600 mg amd 800 mg. Mean exercise duration increased from 327±41 seconds (control) to 399±49 seconds (P<0.01) after tiapamil 600 mg and from 314±39 seconds (control) to 416±49 seconds after tiapamil 800 mg, P<0.001. There was an associated improvement in mean exercise time to onset of I mm ST-segment depression from 240±41 seconds (control) to 300±48 seconds in 10 patients after tiapamil 600 mg, (P<0.02) and from 206±35 seconds (control) to 272±51 seconds in 9 patients after tiapamil 800 mg, P<0.01. Two patients were free of angina and 1 patient normalized his ST-segments after tiapamil 800 mg. Dose-dependent side-effects were mild and tolerable. Tiapamil is safe and highly effective in improving exercise tolerance and relieving myocardial ischaemia in patients with chronic stable angina. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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