Specific bronchoalveolar lavage fluid T cells associate with disease in a pair of monozygotic twins discordant for sarcoidosis.

Autor:	Grunewald, J., Eklund, A., Grunewald, I
Předmět:	T cell receptors BRONCHOALVEOLAR lavage SARCOIDOSIS BODY fluids CELL receptors COMPARATIVE studies DISEASE susceptibility RESEARCH methodology MEDICAL cooperation RESEARCH T cells TWINS HLA-B27 antigen SYMPTOMS EVALUATION research ACUTE diseases
Zdroj:	Journal of Internal Medicine; Dec2001, Vol. 250 Issue 6, p535-539, 5p, 1 Black and White Photograph, 1 Chart, 1 Graph
Abstrakt:	A 49-year-old Caucasian woman had an acute onset of sarcoidosis. Bronchoscopy with bronchoalveolar lavage (BAL) showed a pronounced accumulation of BAL fluid CD4+ T cells expressing the T-cell receptor (TCR) AV2S 3 gene. In line with this observation, the patient was HLA-DR 17 positive, previously shown to strongly correlate with lung compartmentalized AV2S3+ T cells. At follow-up after recovery, reduced numbers of BAL fluid AV2S3+ T cells were found. Interestingly, BAL fluid of a healthy monozygotic twin sister contained normal numbers of AV2S3+ lung T cells. This report shows the T-cell repertoire of BAL fluid T cells to correlate with the disease (sarcoidosis). indicating a local and specific immune response triggered by an unknown antigen in sarcoidosis. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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