Sorting and Manipulation of Magnetic Droplets in Continuous Flow.

Autor: Al-Hetlani, Entesar, Hatt, Oliver J., Vojtísˇek, Martin, Tarn, Mark D., Iles, Alexander, Pamme, Nicole
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Zdroj: AIP Conference Proceedings; 12/2/2010, Vol. 1311 Issue 1, p167-175, 9p
Abstrakt: We report the rapid on-chip generation and subsequent manipulation of magnetic droplets in continuous flow. Magnetic droplets were formed using aqueous-based ferrofluid as the dispersed phase and fluorocarbon oil as the continuous phase. Droplet manipulation was demonstrated with simple permanent magnets using two microfluidic platforms: (i) flow focusing droplet generation followed by their splitting into daughter droplets containing different amounts of magnetic nanoparticles, and (ii) droplet generation at a T-junction and their downstream deflection across a chamber for sorting based on the applied magnetic field and magnetite loading of the droplet. Both systems show great potential for performing a wide range of high throughput continuous flow processes including sample dilution, cell sorting and screening, and microparticle fabrication. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index