| Autor: |
Nikitin, Maxim, Yuriev, Mikhail, Brusentsov, Nikolai, Vetoshko, Petr, Nikitin, Petr |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 12/2/2010, Vol. 1311 Issue 1, p452-457, 6p |
| Abstrakt: |
Quantitative detection of magnetic nanoparticles (MP) in vivo is very important for various biomedical applications. Our original detection method based on non-linear MP magnetization has been modified for non-invasive in vivo mapping of the MP distribution among different organs of rats. A novel highly sensitive room-temperature device equipped with an external probe has been designed and tested for quantification of MP within 20-mm depth from the animal skin. Results obtained by external in vivo scanning of rats by the probe and ex vivo MP quantification in different organs of rats well correlated. The method allows long-term in vivo study of MP evolution, clearance and redistribution among different organs of the animal. Experiments showed that dynamics in vivo strongly depend on MP characteristics (size, material, coatings, etc.), site of injection and dose. The developed detection method combined with the magnetic nanolabels can substitute the radioactive labeling in many applications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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