| Autor: |
Silva, Giovanilton Ferreira da, Albuquerque, José Sílvio Veras, de Oliveira, Caroliny Gomes, Nogueira, Ricardo Emilio Ferreira Quevedo, Ferreira, Andrea Lopes de Oliveira |
| Předmět: |
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| Zdroj: |
International Journal of Chemical Engineering (1687806X); 2009, Special section p1-5, 5p, 1 Black and White Photograph, 2 Diagrams, 5 Graphs |
| Abstrakt: |
Semisynthetic beta-lactam antibiotics are among the most used pharmaceuticals. Their use in veterinary and human medicine is in continuous expansion. There is a growing need for developing bioactive implants. Advantages of implantable drug delivery tools can include high release efficiency, precise dose control, low toxicity, and allow to overcome disadvantages connected with conventional methods. In this respect, hydroxyapatite (HA) is an elective material. It enables to produce architectures similar to those of real bones. Here we studied a kineticmodel to describe ampicillin release fromHA. In the course of adsorption experiment, ampicillin was dissolved, maintained at 30°C and shaken at 60 strokes/minute. Samples were withdrawn periodically for analysis and then returned to the mixture. Adsorbed amounts were measured by the difference of the concentration of the antibiotics before and after adsorption using UV adsorption at 225 nm. The aim of this work was to evaluate its application as ampicillin delivery carrier. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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