Preliminary evaluation of acute toxicity of 188Re-BMEDA-liposome in rats.

Autor: Chi-Mou Liu, Chih-Hsien Chang, Ya-Jen Chang, Chin-Wei Hsu, Liang-Cheng Chen, Hsiao-Lin Chen, Chung-Li Ho, Chia-Yu Yu, Tsui-Jung Chang, Tung-Chuan Chiang, Te-Wei Lee
Předmět:
Zdroj: Journal of Applied Toxicology; Oct2010, Vol. 30 Issue 7, p680-687, 8p
Abstrakt: The article presents a study which preliminary evaluates the acute radiotoxicity of 188Re-BMEDA-liposome in rats. The study involves the administration of 188Re-BMEDA-liposome in rats with normal saline which serves as blank or non-radioactive liposome through intravenous route. It concludes that the presence of dicentric chromosomes in rats were linked with the dosage of 188Re-BMEDA-liposome.
Databáze: Complementary Index