| Autor: |
Plotnikov, M., Smolyakova, V., Ivanov, I., Chernisheva, G., Kuchin, A., Chukicheva, I., Krasnov, E. |
| Předmět: |
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| Zdroj: |
Bulletin of Experimental Biology & Medicine; Jun2010, Vol. 149 Issue 6, p721-723, 3p |
| Abstrakt: |
Hemorheological activity of 4-methyl-2,6-di-isobornyl phenol, a new o-isobornyl phenol derivative, was studied under conditions of experimental prolonged partial cerebral ischemia. Brain ischemia is associated with hemorheological disorders which can be characterized as blood hyperviscosity syndrome: increased viscosity of the whole blood (within a wide range of shear rates), plasma viscosity, fi brinogen content in blood plasma, and platelet aggregation; deterioration of platelet deformability and reduced availability of oxygen for tissues. A course (5 days) of intragastric 4-methyl-2,6-di-isobornyl phenol (100 mg/kg) prevented the development of blood hyperviscosity syndrome by modulating blood macrorheology (reduction of plasma viscosity and fi brinogen content) and microrheology (reduction of erythrocyte aggregation and improvement of their deformability). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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