| Autor: |
Loffeld, Rjlf, Werdmuller, Bibi Fm, Putten, Toon Bmm Van Der, Balk, Ton G, Lamers, Cornelius Bhw, Loffeld, Ruud Jlf |
| Předmět: |
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| Zdroj: |
Journal of Gastroenterology & Hepatology; May2000, Vol. 15 Issue 5, p498-502, 5p, 3 Charts |
| Abstrakt: |
Abstract Background: A questionnaire was used to record the clinical presentation of functional dyspepsia in relation to Helicobacter pylori infection in a consecutive series of patients sent for upper gastrointestinal endoscopy. Only patients without macroscopic abnormalities in their oesophagus, stomach and duodenum were included. Methods: The study questionnaire included two questions related to daily life, and the calculation of a symptom score. Biopsy specimens were taken from all patients for histological and microbiological examination, and immunoglobulin G antibodies were also determined. Results: Two hundred and twenty-two patients were H. pylori positive and 182 patients were H. pylori negative. Loss of weight was significantly more common in the H. pylori positive group (P < 0.001). Patients with H. pylori infection had a significantly higher overall symptom score compared with H. pylori-negative subjects (P < 0.05). In addition, the severity of epigastric and nocturnal pain, heartburn, retrosternal heartburn, and vomiting was significantly higher in H. pylori-positive functional dyspeptic patients, and the influence on daily life and activities was significantly worse. Conclusions: The combination of retrosternal pain, weight loss, food intolerance and the absence of halitosis signified a 64% accuracy in predicting H. pylori infection. It is not possible to differentiate between H. pylori-positive and H. pylori-negative functional dyspeptics on the basis of clinical presentation and the number of complaints. However, overall symptom score and severity of several symptoms was significantly higher in the H. pylori-positive group. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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