| Autor: |
Dowling, Damian J, John, D James B St, Macrae, Finlay A, Hopper, John L |
| Předmět: |
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| Zdroj: |
Journal of Gastroenterology & Hepatology; Aug2000, Vol. 15 Issue 8, p939-944, 6p, 2 Charts |
| Abstrakt: |
AbstractBackground and Aims: People with a strong family history of common (so-called ‘sporadic’) colorectal cancer are generally advised to undergo colonoscopic screening, but the starting age for this is unclear. An audit was performed to study the age-related yield of screening colonoscopy in this risk group. Methods: A prospective audit of the outcome of screening colonoscopy was performed on a cohort of 232 people with a strong family history of common colorectal cancer. All were registrants in a familial bowel cancer service solely because of their family medical history. They had no bowel symptoms and no prior endoscopic investigation of the large bowel. Results: Neoplastic lesions were detected by using colonoscopy in 33 participants. In 27 participants, the major lesion was a small tubular adenoma, four had an advanced adenoma and two had cancer. More neoplastic (P = 0.02) and advanced neoplastic (P = 0.03) lesions were found in those patients aged ≥ 50 years. Only one advanced adenoma was detected in a participant below the age of 50 years. Conclusion: The yield from screening colonoscopy in young people (< 50 years) with a strong family history of common colorectal cancer is low, placing doubt on the need for colonoscopic screening before the age of 50 years. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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