Relationships in Dissolution and Solvation of Miconazole Nitrate in Binary and Ternary Solvents Based on Polyethylene Glycol-400.

Autor: Krasnoperova, A., Sytnik, O., Yukhno, G., Bezuglaya, E., Lyapunov, N.
Zdroj: Russian Journal of Applied Chemistry; 2002, Vol. 75 Issue 12, p1935-1938, 4p
Abstrakt: The solubility of 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole nitrate (miconazole nitrate) CHClNO · HNO in binary mixtures 1,2-propylene glycol-polyethelene glycol-400 and in ternary mixtures of these glycols with water at 293.15 K was studied. The correlation between the miconazole nitrate solubility and the dielectric constant of the solvents was discussed. The deviations of the miconazole nitrate solubility from additivity throughout the composition range of mixed solvents were calculated. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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