Translating tissue-engineered tracheal replacement from bench to bedside.

Autor:	Kalathur, Madhuri, Baiguera, Silvia, Macchiarini, Paolo
Předmět:	TRACHEA GENETIC translation RESPIRATORY diseases TRANSPLANTATION of organs tissues etc. MESENCHYMAL stem cells REGENERATIVE medicine TISSUE engineering EPITHELIAL cells
Zdroj:	Cellular & Molecular Life Sciences; Dec2010, Vol. 67 Issue 24, p4185-4196, 12p
Abstrakt:	There are a variety of airway diseases with different clinical settings, which may extend from a surgical approach to total organ replacement. Tissue engineering involves modifying cells or tissues in order to repair, regenerate, or replace tissue in the body and seems to be a promising approach for airway replacement. The successful implantation of stem-cell-based tissue-engineered trachea in a young woman with end-stage post-tuberculosis left main bronchus collapse serves as a prototype for the airway tissue-engineered-based approach. The trachea indeed could represent a perfect model system to investigate the translational aspects of tissue engineering, largely due to its low-oxygen needs. This review highlights the anatomy of the airways, the various disease conditions that cause damage to the airways, elaborates on the essential components of the tissue-engineering approach, and discusses the success of the revolutionary trachea transplantation approach. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink