| Autor: |
Dionisio, Daniele, Vivarelli, Angela, Zazzi, Maurizio, Esperti, Francesco, Uberti, Manuela, Polidori, Marina |
| Předmět: |
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| Zdroj: |
Clinical Infectious Diseases; 9/1/2001, Vol. 33 Issue 5, p1, 4p |
| Abstrakt: |
Little is known about factors involved in virological response to treatment changes guided by genotyping in patients whose highly active antiretroviral therapy (HAART) fails. A 12-month observational study was con-ducted of 45 patients infected with human immunodeficiency virus (HIV)--1, who underwent a new genotype-guided HAART regimen following virological treatment failure. Logistic regression models were used to define factors predictive of virological response to genotype-assisted treatment switches. Virological response was defined as achievement of a level of plasma HIV-1 RNA !1000 copies/mL at the end of the follow-up. Drug-resistance mutations were detected at baseline in 30 patients (66.7%). A sustained virological response to new treatment occurred in 13 (43.3%) of these, as opposed to 11 (73.3%) of the 15 patients harboring drug-susceptible virus at baseline ( ). In multivariate logistic regression analysis, the number of drug classes P p .07 where there was resistance at baseline was the only independent predictor of virological failure ( ). P p .0313 Lack of virological response to genotype-guided treatment changes is primarily due to complex baseline resistance patterns. Benefits of antiretroviral resistance testing may be seriously limited by the lack of sub-sequent treatment options for heavily pretreated patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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