Rapid endoscopic improvement is important for 1-year avoidance of colectomy but not for the long-term prognosis in cyclosporine A treatment for ulcerative colitis.

Autor: Kobayashi, Taku, Naganuma, Makoto, Okamoto, Susumu, Hisamatsu, Tadakazu, Inoue, Nagamu, Ichikawa, Hitoshi, Takayama, Tetsuro, Saito, Riko, Sujino, Tomohisa, Ogata, Haruhiko, Iwao, Yasushi, Hibi, Toshifumi
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Zdroj: Journal of Gastroenterology; Nov2010, Vol. 45 Issue 11, p1129-1137, 9p, 1 Diagram, 4 Charts, 5 Graphs
Abstrakt: Background: Intravenous (IV) cyclosporine A (CSA) is one of the treatments of choice for patients with steroid-refractory severe ulcerative colitis (UC). In this study, we evaluated the overall experience with CSA treatment in UC patients, from their initial response to long-term prognosis. Methods: The medical records of 72 patients admitted to our hospital with a severe UC flare-up and treated with IV CSA between November 1996 and October 2008 were reviewed retrospectively. The initial response to CSA was assessed using a clinical activity index, and colectomy was assigned as the endpoint for the long-term prognosis. Results: Overall, 53 of 72 (73.6%) patients responded initially to CSA. We could not determine any specific parameters that predicted an initial response. A life-table analysis for all patients revealed that 54.4% of patients required a colectomy within 11 years. The long-term risk of surgery was associated with a shorter disease duration, history of adverse reactions against medications and lack of immunomodulator use. In addition, endoscopic improvement at day 14 was associated with colectomy at 1 year, but not with the long-term prognosis. Conclusions: Although CSA can exert high initial efficacy for severe attacks of UC, >50% of patients who relapse require a colectomy. Specifically, mucosal healing evaluated by endoscopy was associated with the 1-year colectomy rate. In contrast, a history of adverse drug reactions was correlated with the long-term colectomy rate. Therefore, we propose that treatment of severe UC with CSA requires consideration of both initial remission and long-term maintenance as management goals. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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