| Autor: |
Perno, Carlo F., Cozzi-Lepri, Alessandro, Balotta, Claudia, Forbici, Federica, Violin, Michela, Bertoli, Ada, Facchi, Guido, Pezzotti, Patrizio, Cadeo, Gianpiero, Tositti, Giulio, Pasquinucci, Sandro, Pauluzzi, Sergio, Scalzini, Alfredo, Salassa, Bernardino, Vincenti, Antonella, Phillips, Andrew N., Dianzani, Ferdinando, Appice, Amelia, Angarano, Gioacchino |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 10/15/2001, Vol. 184 Issue 8, p983, 9p |
| Abstrakt: |
The role of mutations in protease (PR) and reverse-transcriptase (RT) of human immunodeficiency virus (HIV) in predicting virologic failure was assessed in 248 antiretroviral-naive HIV-positive patients who began a PR inhibitor—containing antiretroviral regimen. Genotypic testing was performed on plasma samples stored before the start of therapy. Twenty-seven patients (10.9%) had mutations in the RT, 5 (2%) carried primary mutations in the PR, and 131 (52.8%) showed only secondary PR mutations. Virologic failure at week 24 occurred in 62 (25.0%) of 248 patients. There was a statistically significant correlation between virologic failure and the number of PR mutations (P = .04, x² test). Mutations at codons 10 and 36 of PR (present in 39.3% and 40.0% of patients in whom treatment failed, respectively) were identified by stepwise logistic regression as the strongest predictors of virologic failure (odds ratio, 2.20; 95% confidence interval, 1.30–3.75; P = .004). If confirmed in independent studies, this result may justify the increased use of HIV genotyping in drug-naive patients requiring antiretroviral therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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