| Autor: |
Nicholas, Terence E., Doyle, Ian R., Morton, Sharon, Crockett, Alan J., Barr, Heather A., Davidson, Kate G., Jones, Meril J., Jones, Michael E. |
| Předmět: |
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| Zdroj: |
Respirology; Sep2000, Vol. 5 Issue 3, p211-220, 10p |
| Abstrakt: |
Objective:We test the hypothesis that the changes we observed previously in the relative amounts of disaturated phospholipids (DSP), cholesterol (CHOL), and surfactant protein-A (SP-A) in human alveolar surfactant in response to acute exercise, and which were related to fitness, can be induced by training. Methodology:We examine the effect of 7 weeks' training on these major surfactant components, together with surfactant protein-B (SP-B), in bronchoalveolar lavage fluid harvested from 17 males, both at rest and after acute exercise. Fitness was assessed as workload/heart rate achieved during cycling for 30 min at 90% of theoretical maximal heart rate, and was increased in all subjects following training (mean increase 22.2 ± 3.91%; P = 0.001). Results:Training significantly increased the SP-A/DSP, SP-B/DSP, SP-A/CHOL and SP-A/SP-B ratios in whole surfactant harvested from subjects both at rest and immediately following exercise. Training also increased the SP-B/CHOL ratio at rest. Changes were particularly marked at rest in the SP-A/DSP, SP-A/CHOL, and SP-B/CHOL ratios in the tubular myelin-rich fraction, and after exercise in the SP-A/DSP, SP-A/CHOL, and SP-A/SP-B ratios in the tubular myelin-poor fraction. Conclusion:We conclude that training markedly alters the composition of alveolar surfactant both at rest and with exercise; the physiological significance of these changes remains to be determined. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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