Toxic shock syndrome associated with newly diagnosed type I diabetes.

Autor:	Couper, Jj, Kallincos, N, Pollard, A, Honeyman, M, Prager, P, Harrison, Lc, Rischmueller, M, Couper, J, Couper, J J, Harrison, L C
Předmět:	TOXIC shock syndrome DIABETES complications in children ANTIGEN analysis AUTOIMMUNE disease diagnosis ANTIBIOTICS AUTOIMMUNE diseases INSULIN TYPE 1 diabetes LONGITUDINAL method SEPTIC shock STAPHYLOCOCCAL diseases DISEASE complications
Zdroj:	Journal of Paediatrics & Child Health; Jun2000, Vol. 36 Issue 3, p279-282, 4p, 3 Graphs
Abstrakt:	Studies of two post-mortem pancreata of children at the onset of type I diabetes have suggested activation and expansion of islet infiltrating T cells by a superantigen. We present the first reported case of a superantigen mediated disease, toxic shock syndrome (TSS), occurring at the diagnosis of type I diabetes. A 12-year-old girl presented with TSS and newly diagnosed diabetes with ketoacidosis. At presentation she was unconscious, febrile and hypotensive, with a desquamating erythematous rash and Kussmaul breathing. During resuscitation, her renal impairment, diarrhoea, thrombocytopaenia and ketoacidosis resolved. Vaginal discharge and blood cultures grew Staphylococcus aureus. T cell studies at 2 weeks after diagnosis detected a high level of spontaneous and islet antigen-specific proliferation with associated interleukin-10 production compared to human leucocyte antigen DR matched controls. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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