| Autor: |
Rassnick, K. M., Bailey, D. B., Malone, E. K., Intile, J. L., Kiselow, M. A., Flory, A. B., Barlow, L. L., Balkman, C. E., Barnard, S. M., Waite, A. H. |
| Předmět: |
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| Zdroj: |
Veterinary & Comparative Oncology; Dec2010, Vol. 8 Issue 4, p243-253, 12p, 4 Charts, 2 Graphs |
| Abstrakt: |
An -CHOP protocol with interposed treatments of CCNU and MOPP (-CHOP-CCNU-MOPP) was evaluated in 66 dogs with stages III-V lymphoma. Results were compared with a historical group of 71 dogs treated with an -CHOP protocol. Complete remission (CR) rates (85 and 80%, respectively) did not differ significantly between protocols ( P = 0.48). First CR duration for dogs treated with -CHOP-CCNU-MOPP was significantly longer: median, 317 days; 2-year CR rate, 35% versus median, 298 days; 2-year CR rate, 13%, P = 0.05). For the -CHOP-CCNU-MOPP protocol, dogs in substage-b had a 4.3 times greater hazard of having a relapse than dogs in substage-a ( P = 0.002). Frequency of adverse chemotherapy-associated gastrointestinal effects did not differ between protocols ( P = 0.77). Neutropenia (primarily after CCNU) occurred more frequently in dogs treated with -CHOP-CCNU-MOPP ( P < 0.001). In summary, the -CHOP-CCNU-MOPP protocol showed an improved duration of first CR as compared with an -CHOP protocol, but the relevance of this finding might be subject to clinical judgement. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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