| Autor: |
Mustafin, R. I., Bobyleva, O. L., Bobyleva, V. L., Van den Mooter, G., Kemenova, V. A. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Jun2010, Vol. 44 Issue 6, p319-323, 5p, 1 Diagram, 1 Chart, 2 Graphs |
| Abstrakt: |
New interpolyelectrolyte complexes (IPEC) between oppositely charged types of Eudragit, EPO and L100-55, with different molar ratios were synthesized with the aim of seeking potential carriers for oral delivery systems. Elemental analysis showed that the resulting polycomplexes had different compositions, with 0.36 < Z = [EPO]/[L100] < 1.81. The structural properties of the materials assessed by IR spectroscopy and modulated-temperature differential scanning calorimetry showed that all IPEC were stabilized by a cooperative system of ionic bonds, were chemically homogeneous, and were characterized by the presence of a single glass transition temperature. These properties suggest that the polycomplexes synthesized here have potential for further study as carriers for controlled drug release in specified parts of the gastrointestinal tract. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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