Tamoxifen and Breast Cancer Incidence Among Women With Inherited Mutations in BRCA1 and BRCA2.

Autor: King, Mary-Claire, Wieand, Sam, Hale, Kathryn, Lee, Ming, Walsh, Tom, Owens, Kelly, Tait, Jonathan, Ford, Leslie, Dunn, Barbara K., Costantino, Joseph, Wickerham, Lawrence, Wolmark, Norman, Fisher, Bernard
Předmět:
Zdroj: JAMA: Journal of the American Medical Association; 11/14/2001, Vol. 286 Issue 18, p2251, 6p, 5 Charts
Abstrakt: Presents a study to evaluate the effect of tamoxifen on the incidence of breast cancer among cancer-free women with inherited BRCA1 or BRCA2 mutations. Context; Objective; Design, setting, and participants; Main outcome measure; Results; Conclusion that tamoxifen reduced breast cancer incidence among healthy BRCA2 carriers by 62 percent.
Databáze: Complementary Index