How common are polycystic ovaries and the polycystic ovarian syndrome in women with Cushing's syndrome?

Autor: Kaltsas, G. A., Korbonits, M., Isidori, A. M., Webb, J. A. W., Trainer, P. J., Monson, J. P., Besser, G. M., Grossman, A. B.
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Zdroj: Clinical Endocrinology; Oct2000, Vol. 53 Issue 4, p493-500, 08p
Abstrakt: OBJECTIVEWomen with Cushing's syndrome (CS) may present with menstrual irregularity and symptoms/signs of hyperandrogenism, a phenotype similar to that of the polycystic ovarian syndrome (PCOS); however, currently there are no data on the prevalence of either polycystic ovaries (PCO) and/or PCOS in patients with CS. The aim of this study was to investigate their presence among women of reproductive age presenting with CS by analysing clinical, endocrinological and ultrasonographic features. DESIGNProspective study of all women within the reproductive age (range 18–40 years) who presented with CS between August 1994 and January 2000. SUBJECTS AND METHODS Thirteen women (median age 32 years, range 18–39 years) with CS were evaluated. The diagnosis of CS was based on the presence of appropriate clinical features and an elevated serum midnight cortisol with failure to suppress 0900 hours serum cortisol to less than 50 nmol/l following a formal low-dose dexamethasone suppression test (LDDST). All women had their clinical features relevant to possible hyperandrogenism, menstrual disorder and infertility recorded, and circulating gonadotrophins, oestradiol, androgens and SHBG levels measured; ovarian ultrasonography was performed during their initial assessment. Relevant MR/CT imaging of the pituitary and/or adrenal glands was performed. RESULTSEleven women had ACTH-dependent CS [nine Cushing's disease (CD), one ectopic ACTH syndrome due to a bronchial carcinoid, one periodic CS of unknown origin); two patients had ACTH-independent CS (adrenal adenomas). All women with CS had at least one symptom/sign of hyperandrogenism (13 hirsutism, seven acne, five male-pattern alopecia). Nine women (70%) had menstrual disturbances (four oligomenorrhoea, four amenorrhoea, one polymenorrhoea) while four women (30%) had a normal menstrual pattern. Serum oestradiol levels for the group as a whole were similar to those observed in the early follicular phase of normally... [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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