Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Autor: Steffan, Joan S., Bodai, Laszlo, Pallos, Judit, Poelman, Marnix, McCampbell, Alexander, Apostol, Barbara L., Kazantsev, Alexsey, Schmidt, Emily, Ya-Zhen Zhu, Greenwald, Marilee, Kurokawa, Riki, Housman, David E., Jackson, George R., Marsh, J. Lawrence, Thompson, Leslie M.
Předmět:
Zdroj: Nature; 10/18/2001, Vol. 413 Issue 6857, p739, 5p, 4 Color Photographs, 5 Diagrams, 11 Graphs
Abstrakt: Investigates the molecular basis in the development of Huntington's disease. Expansion of a repeated sequence of the amino acid glutamine in abnormal protein huntingtin; Arrest of degeneration through the action of histone deacetylase inhibitors; Potential of including inhibitors in therapy.
Databáze: Complementary Index